Methotrexate

Updated February 2023

What is methotrexate?

Download button - information sheet

Methotrexate is a medication used to treat certain childhood rheumatic conditions (diseases which may affect joints, muscles, skin or eyes). These include juvenile arthritis (JIA), lupus (also known as SLE), uveitis, dermatomyositis and scleroderma.

Methotrexate is a medication that works by suppressing the immune system. It reduces the damage done by inflammation, rather than just reducing pain. Because of this, it is called a disease modifying antirheumatic drug (DMARD). Other medications in this group include leflunomide, sulfasalazine and hydroxychloroquine.

Methotrexate is thought to work by affecting the immune system. It has been safely used for over 30 years. It is one of the most common medications used by rheumatologists. It is also used at very high doses to treat some childhood cancers.