Teriparatide

• While taking teriparatide you should see your rheumatologist or other specialist regularly to make sure the treatment is working and to minimise any possible side effects.
• If you are worried about any side effects you should contact your specialist as soon as possible.
• Teriparatide should not be taken with some other osteoporosis medicines such as bisphosphonates e.g. alendronate (Fosamax, Alendro, Fosamax Plus), risedronate (Actonel, Actonel Combi, Actonel Combi D) and zolendronate (Aclasta), or denosumab (Prolia), romosozumab (Evenity) or raloxifene (Evista). These should be stopped before you start teriparatide.

Bone is constantly changing with older bone being broken down and new bone being formed to take its place. This usually happens in a balanced way. If the cycle becomes unbalanced bone breaks down faster than it is replaced. This leads to osteoporosis.

Teriparatide is a manufactured form of a substance called parathyroid hormone, which is found naturally in the body and has an important role in maintaining healthy bones. Teriparatide helps build bone, making it stronger and lowering the chances of fractures.  

Since osteoporosis is usually not painful (until a fracture occurs) you will not ‘feel’ any immediate benefit from your treatment with teriparatide.

The treatment controls osteoporosis but does not cure it. It is therefore important to continue to use teriparatide even if you feel well.

Do not stop using teriparatide until your doctor tells you to.

You may be asked to have tests to check the effect of treatment on your bones. For example a bone mineral density test is usually done one or two years after first starting teriparatide. This is a type of X-ray that involves a very small amount of radiation.

Tests of urine or blood are also sometimes used to measure the effects of treatment on bone formation and breakdown.

To make sure it is effective it is very important that you follow the instructions for using teriparatide carefully, including the instructions for storage and disposal. Ask your doctor or pharmacist to explain anything you do not understand.

Teriparatide is given as an injection under the skin (subcutaneously). It is injected in the thigh or abdomen once a day. It comes in a pen- shaped device to make the daily injection easier. The teriparatide pen contains enough medicine for 28 doses.

It is important to use a new needle for each injection.

What is the dosage and when should it be given?

The teriparatide daily dose is 20 micrograms.

Use it at around the same time every day to help you remember. The best time to take it is at night before going to bed.

If a dose is missed, use it as soon as possible that day. However, if the day has already passed, skip the missed dose and continue having it as usual. Never inject more than one dose per day. Do not use more or less teriparatide or use it more often than prescribed by your doctor.

Can other medicines be taken with teriparatide?

It is safe to take most other medicines when you are taking teriparatide. However, teriparatide should not be taken with some other osteoporosis medicines (see Precautions).

Your doctor will usually recommend that you take calcium and vitamin D as additional treatment for osteoporosis. Do not stop taking these medicines unless advised by your doctor.

How long is the treatment continued?

For osteoporosis, teriparatide treatment is usually given for up to 18 months and not longer. After that, it is recommended to switch to another osteoporosis medicine.

Most people who take teriparatide do not experience side effects. Tell your doctor if you are concerned about possible side effects.

Most common possible side effects

The most common side effects include:

• Nausea or Vomiting: You may feel queasy, especially early in treatment.
• Joint or Bone Pain: Some individuals report mild discomfort in joints or bones.
• Headache: This is generally mild but can occur as your body adjusts to the medicine.
• Dizziness or Light-headedness: This can happen if you stand up too quickly, particularly when starting treatment. To reduce the risk, rise from a seated or lying position gradually.
• Injection Site Reactions: Discomfort, swelling, bruising, or itching can occur at the injection site in about 30% of people. Sit down if you feel dizzy after injecting.

Less common or rare possible side effects

Less common side effects:

• Muscle Cramps or Weakness: Occasional cramping or weakness in the legs or back can occur.
• Heartburn: Report any frequent or severe heartburn.
• Low Energy: Some people may feel fatigued, especially when starting treatment.

• Chest Pain or Difficulty Breathing: Although rare, this may indicate a more serious reaction. Seek immediate medical attention if you experience these symptoms.
• Mood Changes or Depression: Monitor for any mood changes or depression, and discuss these with your doctor.

Warning of very rare side effect

• Studies have shown that teriparatide can increase the risk of bone cancer (sarcoma) in animals when used in high doses from birth. This is why the maximum treatment period for teriparatide is limited to 18 months. Because of these limits, your doctor may ask you to sign a form before starting treatment with this medicine.

Blood tests

• Monitoring blood tests are not usually needed for people taking teriparatide, although sometimes it may be needed.

Other medical conditions

• Teriparatide should not be taken if you have:
  • severe kidney disease or kidney failure
  • Paget’s disease or blood tests suggestive of Paget’s disease
  • bone diseases other than osteoporosis
  • high parathyroid hormone levels
  • a history of bone cancer or
  • any previous radiotherapy.

Use with other medicines

• You should tell your doctor (including your general practitioner, rheumatologist and others) about all medicines you are taking or plan to take. This includes over the counter or herbal/naturopathic medicines. You should also mention your treatment when you see other health professionals.
• Teriparatide should not be taken with some other osteoporosis medicines such as bisphosphonates e.g. alendronate (Fosamax, Alendro, Fosamax Plus), risedronate (Actonel, Actonel Combi, Actonel Combi D) and zolendronate (Aclasta), or denosumab (Prolia), romosozumab (Evenity) or raloxifene (Evista). These should be stopped before you start teriparatide.
• Bisphosphonates may be started or restarted following teriparatide treatment.
• The risk of side effects from the low doses of aspirin used to prevent heart attack and strokes is not increased when taken with teriparatide.

• Keep the medicine in the pen it came in with, the cap on and without a needle attached, tightly closed, and out of reach of children.
• Do not transfer the medicine to a syringe.
• Store it in the refrigerator but do not freeze it.
• Protect it from light.
• Throw away any medicine that is outdated or no longer needed.
• Throw away the pen after 28 days of use even if it is not empty.
• Dispose of used needles in a puncture- resistant container (sharps box). Talk to your doctor or pharmacist about how to dispose of the sharps box.