For the latest COVID information Click Here.
Updated February 2025
This information sheet was written by the Australian Rheumatology Association to help you understand the medicine that has been prescribed for you. It includes important information about: • how you should take your medicine • what are the possible side effects • what tests you will have to monitor your condition • other precautions you should take while you are taking deucravacitinib.
Please read it carefully and discuss it with your doctor. This information sheet is not intended to replace the product information or discussion with your rheumatologist.
Deucravacitinib (brand name Sotyktu®) is a tablet that belongs to a class of medicines called Tyrosine kinase 2 (TYK2) inhibitors. It works by blocking signals involved in inflammation. Blocking these signals in psoriatic arthritis reduces pain, stiffness, swelling and damage in the joints, and reduces skin psoriasis symptoms.
Deucravacitinib is taken by mouth in tablet form. The tablet should be swallowed whole do not crush, break or chew the tablet.
Take this medicine with a full glass of water at the same time each day. It can be taken with or without food.
If you miss a dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.
The usual dose for adults with plaque psoriasis is 6mg taken once a day.
This medicine may be used alone or with other arthritis medicines including:
Deucravacitinib cannot be used with other biologic DMARDs or targeted synthetic DMARDS (such as upadacitinib, tofacitinib, etanercept and adalimumab).
You might experience side effects with your treatment. Tell your doctor if you notice side effects that you think are caused by this medicine. Many side effects disappear when deucravacitinib treatment is stopped.
Most common side effects
Less common or rare side effects
Infections If you have an active infection of any kind, treatment with deucravacitinib will not be started until the infection is treated successfully. You should have screening for some infections such as TB and hepatitis, before commencing treatment with deucravacitinib.
Use with other medications
Deucravacitinib can interact with other medicines. You should tell your doctor (including your GP, rheumatologist and others) about all medicines you are taking or plan to take. This includes over-the-counter or herbal/naturopathic medicines. You should also mention your treatment when you see other health professionals.
Use with alcohol
You may drink alcohol while taking deucravacitinib. However, if you are also taking methotrexate you should be cautious about how much alcohol you drink.
Vaccines
If you are taking deucravacitinib you should not be immunised with ‘live’ vaccines such as: • MMR (measles, mumps and rubella) • Varicella (chicken pox/shingles) • OPV (oral polio virus) • BCG (bacillus calmette guerin) • Japanese Encephalitis or Yellow Fever
Talk with your rheumatologist before receiving any vaccines. Pneumococcal vaccines and the yearly seasonal flu vaccinations are encouraged.
For more information on vaccination including the COVID-19 vaccination click here.
Surgery
If you require surgery for any reason, treatment with deucravacitinib should be stopped one week before surgery. It will be restarted again after the operation at a time agreed by your surgeon and rheumatologist.
Use in pregnancy and when breastfeeding
More detailed information is available here