Baricitinib

• You must see your rheumatologist regularly to make sure the treatment is working and check for possible side effects.
• You should have regular blood tests as suggested by your rheumatologist.
• It is important to tell your rheumatologist if you have a new serious illness such as a serious infection, cancer or heart failure.
• If you are worried about any side effects, you should contact your rheumatologist as soon as possible.
• If you stop baricitinib for any reason, you must contact your rheumatologist. Failure to do so may mean that your treatment may no longer be funded.
• If you plan to become pregnant, you must discuss the timing with your rheumatologist

• You may notice some relief of joint swelling, pain and stiffness within the first 2 to 4 weeks of treatment, though it can take up to 3 months to improve.

• If you stop or delay your baricitinib treatment, your disease may get worse. Keep taking your treatment, unless advised by your rheumatologist to stop or unless serious side effects occur (see Side effects).
• If you stop baricitinib for any reason you must contact your rheumatologist. Failure to do so may mean that your treatment may no longer be funded.

• Medicines like baricitinib are very expensive and are highly funded by Medicare. Certain conditions must be met to receive it.
• Baricitinib will only be given if your disease is active and if standard treatments have not worked.
• It will only be kept going if it helps your condition. This will be checked around 12 weeks after the start of treatment.
• Blood tests are needed during your treatment to watch for side effects and to decide if the treatment is working.
• How often you have blood tests will depend on what other medicines you are taking and what other illnesses you have. Your rheumatologist will advise on this.

Baricitinib is taken by mouth in tablet form. The tablet should be swallowed whole do not crush or break the tablet.

• Take this medicine with a full glass of water at the same time each day. It can be taken with or without food.
• If you miss a dose: Take a dose as soon as you remember. If it is almost time for your next dose, wait until then and take a regular dose. Do not take extra medicine to make up for a missed dose.

• The usual starting dose of baricitinib is one 4mg tablet, (although your doctor may choose to start a lower dose.) This may be reduced to the 2mg tablet dose if you respond well to treatment. If you have poor kidney function you may begin on the 2mg dose.

Baricitinib may be used alone or with other arthritis medicines including:

• other disease modifying anti rheumatic drugs (DMARDs) such as methotrexate
• steroid medicines such as prednisolone or cortisone injections into the joint
• anti-inflammatory medicines (NSAIDs) such as naproxen (Naprosyn®) or ibuprofen (Brufen®, Nurofen®)
• simple pain medicines such as paracetamol.

If you are taking probenecid tell your doctor as you may need a lower dose of baricitinib.

Baricitinib cannot be used with other biologic DMARDs or targeted synthetic DMARDS (such as tofacitinib).

You might experience side effects with your treatment. Tell your doctor if you notice side effects that you think are caused by this medicine. Many side effects disappear when baricitinib treatment is stopped.

Most common side effects

• Baricitinib is associated with an increase in infections. These are mainly viral infections of the upper respiratory tract (nose, throat and sinus infections) and urinary tract infections. Infections may need treatment and baricitinib may need to be stopped for a while if you develop an infection, so it is important to contact your doctor for advice.
• Gastrointestinal related - nausea (feeling sick), vomiting and diarrhea.
• Blood test abnormalities. This can include an increase in some blood components such as platelets and a decrease in others such as two types of white cells and haemoglobin, causing mild anemia. If baricitinib is ceased the blood usually returns to normal.

Less common or rare side effects

• Blood clots in the veins of the legs or lungs and arteries are possible in some people taking baricitinib. This can happen more often in patients with an inflammatory condition. Further risk factors including heart disease will be assessed by your doctor.
• Serious infections such as tuberculosis (TB) are seen rarely, and screening for TB is needed before treatment begins.
• Increases in lipid (cholesterol) levels have been noted in some patients when taking baricitinib and will be checked using blood tests.
• Changes in liver function have been seen. It is recommended to have regular liver function tests.
• Baricitinib increases the risk of getting shingles. If you get a painful skin rash with blisters inform your doctor immediately. Vaccination for shingles should be discussed with your rheumatologist before starting treatment.
• People with rheumatoid arthritis are at increased risk of lymphoma and some other cancers. Medicines that change your immune system like baricitinib may increase this risk.
• Skin cancers have been reported in people taking baricitinib and yearly skin checks are recommended.
• Tell your doctor or pharmacist immediately of any of side effects you experience.
• Blood counts: Although abnormalities are usually mild sometimes baricitinib will cause a severe abnormality of your liver or blood.

Infections

• If you have an active infection of any kind treatment with baricitinib will not be started until the infection is treated successfully.
• Baricitinib will not be given if you have active untreated tuberculosis (TB) or HIV (AIDS) infection as it is likely to make these conditions worse.

 
Use with other medicines

• Baricitinib can interact with other medicines. You should tell all your doctors about all medicines you are taking or plan to take. This includes over the counter or herbal/naturopathic medicines.

Vaccines

• If you are taking baricitinib you should not be immunised with ‘live’ vaccines such as:
• MMR (measles, mumps and rubella), varicella vaccines (chicken pox/shingles) OPV (oral polio virus), BCG (Bacillus Calmette Guerin) or Yellow Fever. Talk with your rheumatologist before receiving any vaccines.
• Pneumococcal vaccines and the yearly seasonal flu vaccinations are encouraged.

• Store baricitinib in a cool, dry place, away from direct heat and light (for example, not in the bathroom)
• Keep all medicines out of reach of children.